Calorie Restriction, Exercise Rejuvenate Nerve Connections

Subscribe to this Blogger's RSS feed
Share

An article published in the Proceedings of the National Academy of Sciences reveals a mechanism for exercise and calorie restriction in delaying some of the effects of aging.*

Joshua R. Sanes and his Harvard University colleagues compared a synapse known as the skeletal neuromuscular junction in young adult and aged mice. Synapses are the connections that exist between nerve cells or nerves and the muscles that they control. In young neuromuscular synapses, nerve endings match up with their receptors on muscle fibers, enabling efficient transmission of brain signals to the muscle. However, in aged synapses, nerve shrinkage can reduce contact with muscle receptors, leading to muscle wasting.

Dr. Sanes’ team found a variety of age-related differences between the synapses of the young and old mice. However, animals fed a calorie-restricted diet had reductions in these age-associated changes. Additionally, one month of exercise performed by 22-month-old mice partially reversed changes that had already occurred.

Editor’s note: The findings raise the question of whether calorie restriction mimetics might elicit similar benefits.

—D. Dye

Reference

* Proc Natl Acad Sci. 2010 Aug 17.

About HerBusyLife

HerBusyLife.com was launched by three women who have been very busy raising families, running companies, cleaning up after everyone and taking care of friends, family and pampered pets! They dreamed of building a site for women, like you, who need a shortcut to great deals, information and support. Our plan is to be like a good friend who ís looking out for you and always seems to know the latest health news, the best diet plans, newest styles and trends, great beauty tips, the best places to shop, where to go for everything, and more!

We hope you will grow with us as we expand the site to include special benefits and privileges for our members, tons of new products and services, and exclusive forums on the subjects that matter most to you.

Welcome! Put your feet up, make yourself comfortable and stay awhile.

Articles